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This can lead to oxidative stress and tissue damage

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These mechanisms lead to the prolonged activation of trigeminal neurons, astrocytes, and microglia around meningeal blood vessels, inflammatory cascades within brain parenchyma reaching the glia limitans, and the dispersal of arachidonic acid (AA) and potassium ions into the perivascular area ( 5 Omega-3 fatty acid and its neuroimmunological effect Two vital types of polyunsaturated fatty acids (PUFAs) are omega-3 and omega-6 PUFAs, named for the position of the first double bond in relation to the end methyl group

Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis (Bansal et al., 2025)

Consistently, cardiomyocytes derived from Flag - Bnip3 ki/ki mice, but not those of the Flag-Bnip3 / mouse, exhibited Flag-BNIP3/BAX complexes (Fig